Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children

Published: The Journal of Pediatrics
Date:
Authors: Robert H Lustig 1 , Michele L Mietus-Snyder, Peter Bacchetti, Ann A Lazar, Pedro A Velasquez-Mieyer, Michael L Christensen
Abstract:
To assess the use of oral glucose tolerance testing (OGTT) to predict efficacy of insulin sensitization (metformin) or suppression (octreotide) because insulin resistance and insulin hypersecretion may impact pharmacotherapeutic efficacy in obese children.

Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes

Published: The Journal of Clinical Pharmacology
Date:
Authors: Michael L Christensen 1 , Bernd Meibohm, Edmund V Capparelli, Pedro Velasquez-Mieyer, George A Burghen, William V Tamborlane
Abstract:
This study assessed the single- and multiple-dose pharmacokinetics of 3 doses (15 mg, 30 mg, and 45 mg) of pioglitazone in 36 adolescents with type 2 diabetes.