Published:
International journal of obesity and related metabolic disorders
Date:
Abstract:
This study investigated (1) the effect of octreotide-LAR (Sandostatin-LAR
Depot; Novartis) on the enteroinsular axis in a biracial cohort of severely
obese adults, (2) whether octreotide suppression of insulin secretion
occurs by both a direct beta-cell effect and through mediating a
glucagon-like peptide 1 (GLP-1) response, and (3) whether differences in
GLP-1 concentrations could explain racial differences in insulin
concentrations.