A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity

Published: The New England Journal of Medicine
Date:
Authors: Aaron S Kelly 1 , Pernille Auerbach 1 , Margarita Barrientos-Perez 1 , Inge Gies 1 , Paula M Hale 1 , Claude Marcus 1 , Lucy D Mastrandrea 1 , Nandana Prabhu 1 , Silva Arslanian 1 , NN8022-4180 Trial Investigators
Abstract:
Background: Obesity is a chronic disease with limited treatment options in pediatric patients. Liraglutide may be useful for weight management in adolescents with obesity.

Optimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight

Published: Diabetes Care
Date:
Authors: William I Sivitz 1 , Lawrence S Phillips 2 3 , Deborah J Wexler 4 , Stephen P Fortmann 5 , Anne W Camp 6 , Margaret Tiktin 7 , Magalys Perez 6 , Jacqueline Craig 8 , Priscilla A Hollander 9 , Andrea Cherrington 10 , Vanita R Aroda 11 , Meng Hee Tan 12 , Jonathan Krakoff 13 , Neda Rasouli 14 , Nicole M Butera 15 , Naji Younes 15 , GRADE Research Group
Abstract:
We evaluated the effect of optimizing metformin dosing on glycemia and body weight in type 2 diabetes.

Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys

Published: The Lancet Global Health
Date:
Authors: NCD Risk Factor Collaboration (NCD-RisC)—Americas Working Group
Abstract:
Describing the prevalence and trends of cardiometabolic risk factors that are associated with non-communicable diseases (NCDs) is crucial for monitoring progress, planning prevention, and providing evidence to support policy efforts. We aimed to analyze the transition in body-mass index (BMI), obesity, blood pressure, raised blood pressure, and diabetes in the Americas, between 1980 and 2014.

External validation of the Finnish diabetes risk score in Venezuela using a national sample: The EVESCAM

Published: Primary Care Diabetes
Date:
Authors: Ramfis Nieto-Martínez 1 , Juan P González-Rivas 2 , Eunice Ugel 3 , Maria Ines Marulanda 4 , Maritza Durán 5 , Jeffrey I Mechanick 6 , Pablo Aschner 7
Abstract:
To evaluate the performance of the Latin American Finnish Diabetes Risk Score (LA-FINDRISC) compared with the original O-FINDRISC in general population. To establish the best cut-off to detect unknown type 2 diabetes (uT2D) and prediabetes.

Diabetes and depression were not associated in Venezuelan adults: The EVESCAM study, a national cross-sectional sample

Published: Primary Care Diabetes
Date:
Authors: Juan Pablo González-Rivas 1 , William Polonsky 2 , María María Infante-García 3 , Maritza Duran 4 , Eunice Ugel 5 , María Ines Marulanda 6 , Jeffrey I Mechanick 7 , Ramfis Nieto-Martínez 8
Abstract:
Evidence suggests that depression is more common in patients with diabetes than in the general population. However, contradictory results expose controversy in this association.

Liraglutide in Children and Adolescents with Type 2 Diabetes

Published: The New England Journal of Medicine
Date:
Authors: William V Tamborlane, Margarita Barrientos-Pérez, Udi Fainberg, Helle Frimer-Larsen, Mona Hafez, Paula M Hale, Muhammad Y Jalaludin, Margarita Kovarenko, Ingrid Libman, Jane L Lynch, Paturi Rao, Naim Shehadeh, Serap Turan, Daniel Weghuber, Timothy Barrett, Ellipse Trial Investigators
Abstract:
Metformin is the regulatory-approved treatment of choice for most youth with type 2 diabetes early in the disease. However, early loss of glycemic control has been observed with metformin monotherapy. Whether liraglutide added to metformin (with or without basal insulin treatment) is safe and effective in youth with type 2 diabetes is unknown.

Prevalence of diabetes in three regions of Venezuela. The VEMSOLS study results

Published: Primary Care Diabetes
Date:
Authors: Ramfis Nieto-Martínez 1 , Jeffrey I Mechanick 2 , Imperia Brajkovich 3 , Eunice Ugel 4 , Alejandro Risques 5 , Hermes Florez 6 , Juan Pablo González-Rivas 7
Abstract:
The prevalence of diabetes in multiple regions of Venezuela is unknown. To determine the prevalence of diabetes in five populations from three regions of Venezuela.

APPLICATION OF THE AACE/ACE ADVANCED FRAMEWORK FOR THE DIAGNOSIS OF OBESITY AND CARDIOMETABOLIC DISEASE STAGING IN A GENERAL POPULATION FROM 3 REGIONS OF VENEZUELA: THE VEMSOLS STUDY RESULTS

Published: Endocrine Practice
Date:
Authors: Ramfis Nieto-Martínez, Juan P González-Rivas, Eunice Ugel, Imperia Brajkovich, Alejandro Risquez, W Timothy Garvey, Jeffrey I Mechanick
Abstract:
To determine the prevalence of obesity according to the American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) framework based on a complications-centric model with further application of the Cardiometabolic Disease Staging (CMDS) system in a Venezuelan population.