LINK TO RESEARCH
International journal of obesity and related metabolic disorders
P A Velasquez-Mieyer 1 ,
P A Cowan,
K L Arheart,
C K Buffington,
K A Spencer,
B E Connelly,
G W Cowan,
R H Lustig
Purpose: Hyperinsulinemia is a common feature of many obesity syndromes. We
investigated whether suppression of insulin secretion, without dietary or
exercise intervention, could promote weight loss and alter food intake and
preference in obese adults.
Methods: Suppression of insulin secretion was achieved using octreotide-LAR 40 mg
IM q28d for 24 weeks in 44 severely obese adults (89% female, 39%
minority). Oral glucose tolerance testing was performed before and after
treatment, indices of beta-cell activity (CIRgp), insulin sensitivity
(CISI), and clearance (CP/I AUC) were computed, and leptin levels, 3-day
food records and carbohydrate-craving measurements were obtained. DEXA
evaluations were performed pre- and post-therapy in an evaluable subgroup.
Results: For the entire cohort, significant insulin suppression was achieved with
simultaneous improvements in insulin sensitivity, weight loss, and body
mass index (BMI). Leptin, fat mass, total caloric intake, and carbohydrate
craving significantly decreased. When grouped by BMI response, high
responders (HR; DeltaBMI<-3 kg/m(2)) and low responders (LR; DeltaBMI between -3 and -0.5) exhibited higher suppression of CIRgp and IAUC than nonresponders (NR; DeltaBMI-0.5). CISI improved and significant declines in leptin and fat mass occurred only in HR and LR. Conversely, both leptin and fat mass increased in NR. Carbohydrate intake was markedly suppressed in HR only, while carbohydrate-craving scores decreased in HR and LR. For the entire cohort, DeltaBMI correlated with DeltaCISI, Deltafat mass, and Deltaleptin. DeltaFat mass also correlated with DeltaIAUC and DeltaCISI. Conclusions: In a subcohort of obese adults, suppression of insulin secretion was associated with loss of body weight and fat mass and with concomitant modulation of caloric intake and macronutrient preference.
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