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Relationship between the Finnish Diabetes Risk Score (FINDRISC), vitamin D levels, and insulin resistance in obese subjects

By February 1, 2017September 24th, 2020No Comments


Primary Care Diabetes

Marcos M Lima-Martínez 1 ,
Carlos Arrau 2 ,
Saimar Jerez 2 ,
Mariela Paoli 3 ,
Juan P González-Rivas 4 ,
Ramfis Nieto-Martínez 5 ,
Gianluca Iacobellis 6

Aim: To assess the relationship between 25-hydroxyvitamin D [25(OH)D] blood
concentrations in subjects with obesity and type 2 diabetes mellitus (T2D)
risk according to the Finnish Diabetes Risk Score (FINDRISC) modified for
Latin America (LA-FINDRISC).
Methods: This study was conducted in Ciudad Bolívar, Venezuela. Eighty two women
and 20 men (53 obese and 49 nonobese), with an average age of 42.6±12.30
years were enrolled. Weight, height, body mass index (BMI), waist
circumference (WC), fasting glucose, basal insulin, plasma lipids,
Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and 25(OH)D
levels were measured. FINDRISC with WC cutoff points modified for Latin
America was applied.
Results: No difference in 25(OH)D levels between obese and nonobese subjects was
found. When anthropometric, clinical, and biochemical variables according
to the 25(OH)D status were compared, the only difference detected was
higher LA-FINDRISC in the insufficient/low 25(OH)D group compared to normal
25(OH)D levels group (12.75±6.62; vs 10.15±5.21; p=0.031). LA-FINDRISC was
negatively correlated with plasma 25(OH)D levels (r=-0.302; p=0.002) and
positively correlated with the HOMA-IR index (r=0.637; p=0.0001).
Conclusions: The LA-FINDRISC significantly correlated with both 25(OH)D levels and
insulin resistance markers in this group of patients.


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