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Facilitators and barriers to successful recruitment into a large comparative effectiveness trial: a qualitative study

By July 1, 2019September 24th, 2020No Comments


Journal of Comparative Effectiveness Research

Stephanie Behringer-Massera 1 ,
Terysia Browne 2 ,
Geny George 3 ,
Sally Duran 3 ,
Andrea Cherrington 4 ,
M Diane McKee 2 5 ,
GRADE Research Group

Background: Recruitment of participants into research studies, especially individuals
from minority groups, is challenging; lack of diversity may lead to biased
findings. Aim: To explore beliefs about research participation among individuals who were
approached and eligible for the GRADE study. Methods: In-depth qualitative telephone interviews with randomized participants (n
= 25) and eligible individuals who declined to enroll (n = 26). Results: Refusers and consenters differed in trust and perceptions of risk,
benefits and burden of participation. Few participants understood how
comparative effectiveness research differed from other types of trials;
however, some features of comparative effectiveness research were perceived
as lower risk. Conclusion: We identified facilitators and addressable barriers to participation in
research studies.


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